CACIPLIQ20® is a Class III medical device indicated for advanced wound management and tissue regeneration. It is based on proprietary RGTA® (ReGeneraTing Agent) technology, designed to restore the extracellular matrix and support physiological wound healing processes, particularly in chronic and hard-to-heal wounds.

Key Product Features:

• RGTA® Technology: A bioengineered agent that mimics the biological role of heparan sulfate glycosaminoglycans. It protects structural proteins of the extracellular matrix and preserves endogenous growth factors, thereby restoring a favorable wound microenvironment.
• Sterile Solution for External Use: Supplied as a ready-to-use sterile solution for topical application.
• Application Frequency: Typically applied approximately twice per week, according to clinical judgment and wound condition.

Available Formats:

• Spray: 7.5 mL sterile solution with integrated sterile pump
• Application Kit: 5 mL vial supplied with sterile compresses for controlled administration
• Preservative-Free Formulation: Designed without preservatives to enhance biocompatibility with compromised tissue.

Indications for Use:

CACIPLIQ20® is indicated for the management of chronic cutaneous wounds that show limited or no healing following appropriate standard wound care, including:

• Pressure injuries
• Ulcers associated with peripheral arterial disease
• Diabetic foot ulcers, including post-amputation wounds
• It is intended for wounds that have failed to demonstrate satisfactory healing over prolonged periods of conventional treatment.

Mechanism of Action:

CACIPLIQ20® acts by stabilizing and protecting key components of the extracellular matrix at the site of tissue injury. By reconstructing the structural framework of the matrix and protecting growth factors from enzymatic degradation, it helps re-establish a biologically active environment that supports cell migration, angiogenesis, and tissue repair.

Clinical Benefits:

• Supports tissue regeneration and wound closure in chronic and refractory wounds
• Preserves and restores extracellular matrix integrity
• Simple and well-tolerated application protocol
• Reduces treatment burden in long-term wound management